Phytochemical screening, toxicological studies of aqueous whole plant extract and characterized conjugated silver nanoparticles on liver function biomarkers

Stephen Dare Oloninefa; Moses Enemaduku Abalaka; Safiya Yahaya Daniyan; Abdullahi Mann; Japhet Erasmus Aisoni; Abdulsalaam Ihima Alli

doi:10.5455/NJEAS.147504

2025, Vol: 3, Issue: 1

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NJEAS. 2023; 1(1):

doi: 10.5455/NJEAS.147504

Phytochemical screening, toxicological studies of aqueous whole plant extract and characterized conjugated silver nanoparticles on liver function biomarkers

Stephen Dare Oloninefa, Moses Enemaduku Abalaka, Safiya Yahaya Daniyan, Abdullahi Mann, Japhet Erasmus Aisoni, Abdulsalaam Ihima Alli.

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Abstract
Assessment of the safety and possible effects aqueous whole plant extract and characterized conjugated silver nanoparticles derived from Euphorbia heterophylla as related to liver function can produce on the end users make toxicological studies a must. The phytochemical screening and toxicological studies of aqueous extract and characterized conjugated silver nanoparticles (CCAgNPs) were carried out using standard techniques. Phytochemicals such as: saponins, flavonoids, terpenoids, cardiac glycosides, tannins, phenols, alkaloids, steroids and reducing sugars were present in aqueous extract of whole plant Euphorbia heterophylla (AQEWEH). There was a reduction in the body weights of Wistar albino rats except an increment at a dose of 600 mg/kgbw. However, the highest average body weight of 176.50 g was obtained when 10 mg/kgbw of AQEWEH was administered to Wistar albino rats while 600 mg/kgbw of CCAgNPs gave the highest body weight of 152.50 g. Increment in serum asparte aminotransferase, alanine aminotransferase, total bilirubin, reduction in total protein and urea concentration are indicative of hepatocellular dysfunction and cholestatic pattern. The implication of this study is that for both AQEWEH and CCAgNPs to be used as therapeutic agents and administered to man and animals, their safety doses must be determined.

Key words: Toxicological studies; Aqueous whole plant; Characterized conjugated silver nanoparticles;Liver function biomarkers; Euphorbia heterophylla

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Pubmed Style

Oloninefa SD, Abalaka ME, Daniyan SY, Mann A, Aisoni JE, Alli AI. Phytochemical screening, toxicological studies of aqueous whole plant extract and characterized conjugated silver nanoparticles on liver function biomarkers. NJEAS. 2023; 1(1): -. doi:10.5455/NJEAS.147504

Web Style

Oloninefa SD, Abalaka ME, Daniyan SY, Mann A, Aisoni JE, Alli AI. Phytochemical screening, toxicological studies of aqueous whole plant extract and characterized conjugated silver nanoparticles on liver function biomarkers. https://www.nilejeas.com/?mno=147504 [Access: June 27, 2026]. doi:10.5455/NJEAS.147504

AMA (American Medical Association) Style

Oloninefa SD, Abalaka ME, Daniyan SY, Mann A, Aisoni JE, Alli AI. Phytochemical screening, toxicological studies of aqueous whole plant extract and characterized conjugated silver nanoparticles on liver function biomarkers. NJEAS. 2023; 1(1): -. doi:10.5455/NJEAS.147504

Vancouver/ICMJE Style

Harvard Style

Oloninefa, S. D., Abalaka, . M. E., Daniyan, . S. Y., Mann, . A., Aisoni, . J. E. & Alli, . A. I. (2023) Phytochemical screening, toxicological studies of aqueous whole plant extract and characterized conjugated silver nanoparticles on liver function biomarkers. NJEAS, 1 (1), -. doi:10.5455/NJEAS.147504

Turabian Style

Oloninefa, Stephen Dare, Moses Enemaduku Abalaka, Safiya Yahaya Daniyan, Abdullahi Mann, Japhet Erasmus Aisoni, and Abdulsalaam Ihima Alli. 2023. Phytochemical screening, toxicological studies of aqueous whole plant extract and characterized conjugated silver nanoparticles on liver function biomarkers. Nile Journal of Engineering and Applied Science, 1 (1), -. doi:10.5455/NJEAS.147504

Chicago Style

Oloninefa, Stephen Dare, Moses Enemaduku Abalaka, Safiya Yahaya Daniyan, Abdullahi Mann, Japhet Erasmus Aisoni, and Abdulsalaam Ihima Alli. "Phytochemical screening, toxicological studies of aqueous whole plant extract and characterized conjugated silver nanoparticles on liver function biomarkers." Nile Journal of Engineering and Applied Science 1 (2023), -. doi:10.5455/NJEAS.147504

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About Nile Journal of Engineering and Applied Science The Nile Journal of Engineering and Applied Sciences publishes original peer-reviewed articles on fundamental and applied research and reviews ... Read more. For best results, please use Internet Explorer or Google Chrome.	Contact Information 1. Prof. Abdulhameed Danjuma Mambo Editor-in-Chief abdulhameed.mambo@nileuniversity.edu.ng 2. Dr. Adekunle Adeleke Associate Editor-in-Chief adekunle.adeleke@nileuniversity.edu.ng 3. Dr. Ifeyinwa Obianyo Managing Editor ifeyinwa.obianyo@nileuniversity.edu.ng